| Definition | Guanosine triphosphate, also known as gtp or guanosine 5'-triphosphoric acid, is a member of the class of compounds known as purine ribonucleoside triphosphates. Purine ribonucleoside triphosphates are purine ribobucleotides with a triphosphate group linked to the ribose moiety. Guanosine triphosphate is soluble (in water) and an extremely strong acidic compound (based on its pKa). Guanosine triphosphate can be found in a number of food items such as parsnip, nance, wild celery, and black salsify, which makes guanosine triphosphate a potential biomarker for the consumption of these food products. Guanosine triphosphate can be found primarily in blood and cerebrospinal fluid (CSF), as well as throughout most human tissues. Guanosine triphosphate exists in all living species, ranging from bacteria to humans. In humans, guanosine triphosphate is involved in several metabolic pathways, some of which include deptropine h1-antihistamine action, gluconeogenesis, tobramycin action pathway, and diphenhydramine h1-antihistamine action. Guanosine triphosphate is also involved in several metabolic disorders, some of which include xanthinuria type II, phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), xanthinuria type I, and the oncogenic action of l-2-hydroxyglutarate in hydroxygluaricaciduria. Moreover, guanosine triphosphate is found to be associated with subarachnoid hemorrhage, epilepsy, neuroinfection, and stroke. Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It can act as a substrate for both the synthesis of RNA during the transcription process and of DNA during DNA replication.Its structure is similar to that of the guanine nucleobase, the only difference being that nucleotides like GTP have a ribose sugar and three phosphates, with the nucleobase attached to the 1' and the triphosphate moiety attached to the 5' carbons of the ribose . |
|---|
