Thymidine-5'-triphosphate, also known as ttp or deoxythymidine 5'-triphosphoric acid, is a member of the class of compounds known as pyrimidine 2'-deoxyribonucleoside triphosphates. Pyrimidine 2'-deoxyribonucleoside triphosphates are pyrimidine nucleotides with a triphosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. Thymidine-5'-triphosphate is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). Thymidine-5'-triphosphate can be found in a number of food items such as kohlrabi, garden tomato (variety), cardoon, and star anise, which makes thymidine-5'-triphosphate a potential biomarker for the consumption of these food products. Thymidine-5'-triphosphate exists in all living species, ranging from bacteria to humans. In humans, thymidine-5'-triphosphate is involved in the pyrimidine metabolism. Thymidine-5'-triphosphate is also involved in few metabolic disorders, which include beta ureidopropionase deficiency, dihydropyrimidinase deficiency, MNGIE (mitochondrial neurogastrointestinal encephalopathy), and UMP synthase deficiency (orotic aciduria).
Belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleoside triphosphates. These are pyrimidine nucleotides with a triphosphate group linked to the ribose moiety lacking a hydroxyl group at position 2.
