Showing chemical card for CDP-choline (CFc000337727)
Record Information
Version
1.0
Creation Date
Update Date
2022-09-14 05:31:42 UTC
Chemfont ID
CFc000337727
Molecule Identification
Common Name
CDP-choline
Definition
Citicoline, also known as cytidine 5'-diphosphocholine or cytidine 5'-(choline diphosphate), is a member of the class of compounds known as pyrimidine ribonucleoside diphosphates. Pyrimidine ribonucleoside diphosphates are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety. Citicoline is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Citicoline can be found in a number of food items such as macadamia nut (m. tetraphylla), wax gourd, millet, and garden tomato (variety), which makes citicoline a potential biomarker for the consumption of these food products. Citicoline can be found primarily in human brain, erythrocyte and intestine tissues. Citicoline exists in all eukaryotes, ranging from yeast to humans. In humans, citicoline is involved in a couple of metabolic pathways, which include phospholipid biosynthesis and plasmalogen synthesis. Citicoline has also been shown to elevate ACTH independently from CRH levels and to amplify the release of other HPA axis hormones such as LH, FSH, GH and TSH in response to hypothalamic releasing factors. These effects on HPA hormone levels may be beneficial for some individuals but may have undesirable effects in those with medical conditions featuring ACTH or cortisol hypersecretion including PCOS, type II diabetes and major depressive disorder .
Belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. These are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety.
