Showing chemical card for 5-phospho-β-D-ribosyl-amine (CFc000337657)
Record Information
Version
1.0
Creation Date
Update Date
2022-09-14 05:31:35 UTC
Chemfont ID
CFc000337657
Molecule Identification
Common Name
5-phospho-β-D-ribosyl-amine
Definition
5-phosphoribosylamine, also known as 5-P-beta-D-ribosyl-amine or pra, is a member of the class of compounds known as pentose phosphates. Pentose phosphates are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. 5-phosphoribosylamine is soluble (in water) and a moderately acidic compound (based on its pKa). 5-phosphoribosylamine can be found in a number of food items such as red bell pepper, common chokecherry, yam, and black walnut, which makes 5-phosphoribosylamine a potential biomarker for the consumption of these food products. 5-phosphoribosylamine exists in all eukaryotes, ranging from yeast to humans. In humans, 5-phosphoribosylamine is involved in several metabolic pathways, some of which include azathioprine action pathway, glutamate metabolism, mercaptopurine action pathway, and thioguanine action pathway. 5-phosphoribosylamine is also involved in several metabolic disorders, some of which include adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (APRT), succinic semialdehyde dehydrogenase deficiency, and hyperinsulinism-hyperammonemia syndrome. Phosphoribosylamine (5PRA) is an intermediate in purine metabolism. It is a precursor to IMP. It is generated from Phosphoribosyl pyrophosphate (PRPP) .
Belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.
