Showing chemical card for 3,4-dihydroxyphenylacetate (CFc000337567)
Record Information
Version
1.0
Creation Date
Update Date
2022-09-14 05:31:25 UTC
Chemfont ID
CFc000337567
Molecule Identification
Common Name
3,4-dihydroxyphenylacetate
Definition
3,4-dihydroxybenzeneacetic acid, also known as dopacetic acid or homoprotocatechuic acid, is a member of the class of compounds known as catechols. Catechols are compounds containing a 1,2-benzenediol moiety. 3,4-dihydroxybenzeneacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa). 3,4-dihydroxybenzeneacetic acid can be synthesized from phenylacetic acid. 3,4-dihydroxybenzeneacetic acid can also be synthesized into homovanillic acid. 3,4-dihydroxybenzeneacetic acid can be found in a number of food items such as mexican groundcherry, orange bell pepper, nuts, and turnip, which makes 3,4-dihydroxybenzeneacetic acid a potential biomarker for the consumption of these food products. 3,4-dihydroxybenzeneacetic acid can be found primarily in blood, cerebrospinal fluid (CSF), feces, and urine, as well as throughout most human tissues. In humans, 3,4-dihydroxybenzeneacetic acid is involved in a couple of metabolic pathways, which include disulfiram action pathway and tyrosine metabolism. 3,4-dihydroxybenzeneacetic acid is also involved in several metabolic disorders, some of which include hawkinsinuria, tyrosinemia, transient, of the newborn, dopamine beta-hydroxylase deficiency, and alkaptonuria. Moreover, 3,4-dihydroxybenzeneacetic acid is found to be associated with alzheimer's disease, encephalitis, and hypothyroidism.
