Showing chemical card for (S)-malate (CFc000337455)
Record Information
Version
1.0
Creation Date
Update Date
2022-09-14 05:31:14 UTC
Chemfont ID
CFc000337455
Molecule Identification
Common Name
(S)-malate
Definition
(s)-malic acid, also known as malate or L-2-hydroxybutanedioic acid, belongs to beta hydroxy acids and derivatives class of compounds. Those are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom (s)-malic acid is soluble (in water) and a weakly acidic compound (based on its pKa). (s)-malic acid can be found primarily in most biofluids, including cerebrospinal fluid (CSF), feces, urine, and cellular cytoplasm, as well as in human prostate tissue. Within the cell, (s)-malic acid is primarily located in the cytoplasm (s)-malic acid exists in all eukaryotes, ranging from yeast to humans. In humans, (s)-malic acid is involved in several metabolic pathways, some of which include congenital lactic acidosis, the oncogenic action of fumarate, pyruvate metabolism, and the oncogenic action of 2-hydroxyglutarate (s)-malic acid is also involved in several metabolic disorders, some of which include the oncogenic action of d-2-hydroxyglutarate in hydroxygluaricaciduria, fumarase deficiency, leigh syndrome, and the oncogenic action of l-2-hydroxyglutarate in hydroxygluaricaciduria. Moreover, (s)-malic acid is found to be associated with anoxia.
Belongs to the class of organic compounds known as beta hydroxy acids and derivatives. Beta hydroxy acids and derivatives are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom.
