Showing chemical card for (S)-dihydroorotate (CFc000337454)
Record Information
Version
1.0
Creation Date
Update Date
2022-09-14 05:31:13 UTC
Chemfont ID
CFc000337454
Molecule Identification
Common Name
(S)-dihydroorotate
Definition
Dihydroorotic acid, also known as (S)-4,5-dihydroorotate or 4,5-dihydroorotic acid, (D)-isomer, belongs to alpha amino acids and derivatives class of compounds. Those are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. Dihydroorotic acid is soluble (in water) and a weakly acidic compound (based on its pKa). Dihydroorotic acid can be found in a number of food items such as brassicas, pot marjoram, agave, and rubus (blackberry, raspberry), which makes dihydroorotic acid a potential biomarker for the consumption of these food products. Dihydroorotic acid exists in all eukaryotes, ranging from yeast to humans. In humans, dihydroorotic acid is involved in the pyrimidine metabolism. Dihydroorotic acid is also involved in few metabolic disorders, which include beta ureidopropionase deficiency, dihydropyrimidinase deficiency, MNGIE (mitochondrial neurogastrointestinal encephalopathy), and UMP synthase deficiency (orotic aciduria). 4,5-Dihydroorotic acid is a derivative of orotic acid which serves as an intermediate in pyrimidine biosynthesis .
Belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
