| Definition | GC-376 is a 3C-like protease (3CLpro or Mpro) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells[A219036]. The compound is known as a direct acting antiviral (DAA) for coronaviruses, and was initially developed using structure-guided design to combat MERS-Cov infections[A219036,A219056]. In addition, GC-376 displays potent activity against various coronaviruses such as feline, ferret, and mink Mpro coronavirus[A219026,A219031,A219036,A219041]. A prodrug of [GC-373], GC-376 has recently been used to test inhibition of SARS-Cov-2 Mpro _in vitro_, and results show potent inhibition of this target[A219036]. These results suggest that GC-376, and its metabolites may have therapeutic potential for Covid-19. |
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