ChemFOnt: Showing chemical card for 13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid (CFc000119578)

Record Information

Version

1.0

Creation Date

2022-08-28 10:25:12 UTC

Update Date

2022-09-13 21:43:17 UTC

Chemfont ID

CFc000119578

Molecule Identification

Common Name

13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid

Definition

13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbut-2-enoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid. It is generated by abkar1 enzyme via a reduction-of-alpha-beta-unsaturated-compounds-pattern1 reaction. This reduction-of-alpha-beta-unsaturated-compounds-pattern1 occurs in human gut microbiota.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
13-Chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0,]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylate	Generator
13-chloro-7,14-Dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylate	Generator

Chemical Formula

C₂₂H₂₁ClO₁₀

Average Molecular Weight

480.85

Monoisotopic Molecular Weight

480.0823246

IUPAC Name

13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid

Traditional Name

13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid

CAS Registry Number

Not Available

SMILES

COC1=C(O)C2=C(OC3=C(C(CO)=C(Cl)C(O)=C3C(O)=O)C(=O)O2)C(C)=C1C(=O)CC(C)C

InChI Identifier

InChI=1S/C22H21ClO10/c1-7(2)5-10(25)11-8(3)17-20(16(27)19(11)31-4)33-22(30)12-9(6-24)14(23)15(26)13(21(28)29)18(12)32-17/h7,24,26-27H,5-6H2,1-4H3,(H,28,29)

InChI Key

WRGCDXHTPNDMPK-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as depsides and depsidones. These are polycyclic compounds that is either a polyphenolic compound composed of two or more monocyclic aromatic units linked by an ester bond (depside), or a compound containing the depsidone structure (depsidone).

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Depsides and depsidones

Sub Class

Not Available

Direct Parent

Depsides and depsidones

Alternative Parents

Substituents

Depsidone
Meta-phthalic acid ester
Phthalate ester
Meta_phthalic_acid
Diaryl ether
Butyrophenone
Salicylic acid or derivatives
Hydroxybenzoic acid
Aryl alkyl ketone
Aryl ketone
Anisole
1,4-dioxepine
Alkyl aryl ether
Dioxepine
Aryl halide
Benzenoid
Dicarboxylic acid or derivatives
Aryl chloride
Vinylogous acid
Carboxylic acid ester
Lactone
Ketone
Carboxylic acid
Carboxylic acid derivative
Organoheterocyclic compound
Oxacycle
Ether
Organohalogen compound
Organochloride
Organooxygen compound
Primary alcohol
Organic oxygen compound
Aromatic alcohol
Hydrocarbon derivative
Alcohol
Organic oxide
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Endogenous (HMDB: HMDB0139169)

Process

Not Available

Role

Not Available

Physical Properties

Predicted Properties

Property	Value	Source
Water Solubility	0.05 g/L	ALOGPS
logP	3.04	ALOGPS
logP	4.49	ChemAxon
logS	-4	ALOGPS
pKa (Strongest Acidic)	1.87	ChemAxon
pKa (Strongest Basic)	-3.2	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	159.82 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	116.57 m³·mol⁻¹	ChemAxon
Polarizability	46.49 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

HMDB0139169

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

Showing chemical card for 13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid (CFc000119578)

MOL for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

3D MOL for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

3D SDF for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

3D-SDF for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

PDB for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

3D PDB for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

SMILES for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

INCHI for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

Structure for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)

3D Structure for CFc000119578 (13-chloro-7,14-dihydroxy-12-(hydroxymethyl)-6-methoxy-4-methyl-5-(3-methylbutanoyl)-10-oxo-2,9-dioxatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-15-carboxylic acid)