ChemFOnt: Showing chemical card for gamma-Glutamylhydroxyproline (CFc000010403)

Record Information

Version

1.0

Creation Date

2022-08-28 10:25:12 UTC

Update Date

2022-09-13 18:57:50 UTC

Chemfont ID

CFc000010403

Molecule Identification

Common Name

gamma-Glutamylhydroxyproline

Definition

gamma-Glutamylhydroxyproline is a dipeptide composed of gamma-glutamate and hydroxyproline. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
g-Glutamylhydroxyproline	Generator
Γ-glutamylhydroxyproline	Generator
Γ-glu-hyp	HMDB
L-Γ-glu-L-hyp	HMDB
L-Γ-glutamyl-L-hydroxyproline	HMDB
Γ-glutamyl-hydroxyproline	HMDB
Glutamate hydroxyproline dipeptide	HMDB
Glutamate-hydroxyproline dipeptide	HMDB
Glutamic acid hydroxyproline dipeptide	HMDB
Glutamic acid-hydroxyproline dipeptide	HMDB
(4R)-L-Γ-glutamyl-4-hydroxy-L-proline	HMDB
(4R)-L-gamma-Glutamyl-4-hydroxy-L-proline	HMDB
L-gamma-Glu-L-hyp	HMDB
L-gamma-Glutamyl-L-hydroxyproline	HMDB
gamma-Glu-hyp	HMDB
gamma-Glutamyl-hydroxyproline	HMDB
(2S,4R)-1-[(4S)-4-Amino-4-carboxybutanoyl]-4-hydroxypyrrolidine-2-carboxylate	HMDB
gamma-Glutamylhydroxyproline	HMDB

Chemical Formula

C₁₀H₁₆N₂O₆

Average Molecular Weight

260.246

Monoisotopic Molecular Weight

260.100836243

IUPAC Name

(2S,4R)-1-[(4S)-4-amino-4-carboxybutanoyl]-4-hydroxypyrrolidine-2-carboxylic acid

Traditional Name

(2S,4R)-1-[(4S)-4-amino-4-carboxybutanoyl]-4-hydroxypyrrolidine-2-carboxylic acid

CAS Registry Number

1801529-32-7

SMILES

N[C@@H](CCC(=O)N1C[C@H](O)C[C@H]1C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C10H16N2O6/c11-6(9(15)16)1-2-8(14)12-4-5(13)3-7(12)10(17)18/h5-7,13H,1-4,11H2,(H,15,16)(H,17,18)/t5-,6+,7+/m1/s1

InChI Key

VKENMLSUUVOQLD-VQVTYTSYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Dipeptides

Alternative Parents

Substituents

Alpha-dipeptide
Gamma-glutamyl alpha-amino acid
Glutamine or derivatives
Proline or derivatives
N-acyl-l-alpha-amino acid
N-acyl-alpha amino acid or derivatives
N-acyl-alpha-amino acid
L-alpha-amino acid
Alpha-amino acid or derivatives
Alpha-amino acid
Pyrrolidine carboxylic acid or derivatives
Pyrrolidine carboxylic acid
N-acylpyrrolidine
Hydroxy fatty acid
Heterocyclic fatty acid
Fatty acyl
Fatty acid
Dicarboxylic acid or derivatives
Tertiary carboxylic acid amide
Pyrrolidine
Amino acid
Secondary alcohol
Carboxamide group
Amino acid or derivatives
Azacycle
Organoheterocyclic compound
Carboxylic acid
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Carbonyl group
Amine
Alcohol
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Endogenous (HMDB: HMDB0029150)

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Process

Not Available

Role

Not Available

Physical Properties

Predicted Properties

Property	Value	Source
Water Solubility	29.5 g/L	ALOGPS
logP	-3.5	ALOGPS
logP	-4.7	ChemAxon
logS	-0.95	ALOGPS
pKa (Strongest Acidic)	1.84	ChemAxon
pKa (Strongest Basic)	9.31	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	141.16 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	57.59 m³·mol⁻¹	ChemAxon
Polarizability	24.6 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0029150

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB112146

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

118243642

PDB ID

Not Available

ChEBI ID

193275

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

Showing chemical card for gamma-Glutamylhydroxyproline (CFc000010403)

MOL for CFc000010403 (gamma-Glutamylhydroxyproline)

3D MOL for CFc000010403 (gamma-Glutamylhydroxyproline)

3D SDF for CFc000010403 (gamma-Glutamylhydroxyproline)

3D-SDF for CFc000010403 (gamma-Glutamylhydroxyproline)

PDB for CFc000010403 (gamma-Glutamylhydroxyproline)

3D PDB for CFc000010403 (gamma-Glutamylhydroxyproline)

SMILES for CFc000010403 (gamma-Glutamylhydroxyproline)

INCHI for CFc000010403 (gamma-Glutamylhydroxyproline)

Structure for CFc000010403 (gamma-Glutamylhydroxyproline)

3D Structure for CFc000010403 (gamma-Glutamylhydroxyproline)