ChemFOnt: Showing chemical card for PIP(20:1(11Z)/18:2(9Z,12Z)) (CFc000006043)

Record Information

Version

1.0

Creation Date

2022-08-28 10:25:12 UTC

Update Date

2022-09-13 18:51:55 UTC

Chemfont ID

CFc000006043

Molecule Identification

Common Name

PIP(20:1(11Z)/18:2(9Z,12Z))

Definition

PIP(20:1(11Z)/18:2(9Z,12Z)) is a phosphatidylinositol phosphate. Phosphatidylinositol phosphates are acidic (anionic) phospholipids that consist of a phosphatidic acid backbone, linked via the phosphate group to a phosphorylated inositol (hexahydroxycyclohexane). Phosphatidylinositol phosphates are generated from phosphatidylinositols, which are phosphorylated by a number of different kinases that place the phosphate moiety on positions 4 and 5 of the inositol ring, although position 3 can also be phosphorylated. Phosphatidylinositols phosphates can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 18 and 20 carbons are the most common. PIP(20:1(11Z)/18:2(9Z,12Z)), in particular, consists of one chain of eicosenoic acid at the C-1 position and one chain of linoleic acid at the C-2 position. The eicosenoic acid moiety is derived from vegetable oils and cod oils, while the linoleic acid moiety is derived from seed oils. The most important phosphatidylinositol phosphate in both quantitative and biological terms is phosphatidylinositol 4-phosphate. Phosphatidylinositol and the phosphatidylinositol phosphates are the main source of diacylglycerols that serve as signaling molecules, via the action of phospholipase C enzymes. Phosphatidylinositols phosphates are usually present at low levels only in tissues, typically at about 1 to 3% of the concentration of phosphatidylinositol.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₄₇H₈₆O₁₆P₂

Average Molecular Weight

969.1237

Monoisotopic Molecular Weight

968.539109728

IUPAC Name

{[(1R,5S)-2,3,4,6-tetrahydroxy-5-({hydroxy[(2R)-3-(icos-11-enoyloxy)-2-(octadeca-9,12-dienoyloxy)propoxy]phosphoryl}oxy)cyclohexyl]oxy}phosphonic acid

Traditional Name

[(1R,5S)-2,3,4,6-tetrahydroxy-5-{[hydroxy(2R)-3-(icos-11-enoyloxy)-2-(octadeca-9,12-dienoyloxy)propoxyphosphoryl]oxy}cyclohexyl]oxyphosphonic acid

CAS Registry Number

None

SMILES

[H][C@@](COC(=O)CCCCCCCCCC=CCCCCCCCC)(COP(O)(=O)O[C@@]1([H])C(O)C(O)C(O)[C@@]([H])(OP(O)(O)=O)C1O)OC(=O)CCCCCCCC=CCC=CCCCCC

InChI Identifier

InChI=1S/C47H86O16P2/c1-3-5-7-9-11-13-15-17-19-20-22-23-25-27-29-31-33-35-40(48)59-37-39(61-41(49)36-34-32-30-28-26-24-21-18-16-14-12-10-8-6-4-2)38-60-65(57,58)63-47-44(52)42(50)43(51)46(45(47)53)62-64(54,55)56/h12,14,17-19,21,39,42-47,50-53H,3-11,13,15-16,20,22-38H2,1-2H3,(H,57,58)(H2,54,55,56)/t39-,42?,43?,44?,45?,46-,47+/m1/s1

InChI Key

QEHYUFJYOPLPRA-CSDMGBHBSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as glycerophosphoinositol phosphates. These are lipids containing a common glycerophosphate skeleton linked to at least one fatty acyl chain and an inositol-5-phosphate moiety.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerophospholipids

Sub Class

Glycerophosphoinositol phosphates

Direct Parent

Glycerophosphoinositol phosphates

Alternative Parents

Substituents

Glycerophosphoinositol phosphate
Diacylglycerophosphoinositol
Glycerophosphoinositol
Inositol phosphate
Cyclohexanol
Fatty acid ester
Dialkyl phosphate
Monoalkyl phosphate
Cyclitol or derivatives
Dicarboxylic acid or derivatives
Organic phosphoric acid derivative
Phosphoric acid ester
Fatty acyl
Alkyl phosphate
Cyclic alcohol
Secondary alcohol
Carboxylic acid ester
Carboxylic acid derivative
Polyol
Alcohol
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Organooxygen compound
Carbonyl group
Aliphatic homomonocyclic compound

Molecular Framework

Aliphatic homomonocyclic compounds

External Descriptors

Not Available

Functional Ontology

All cells and tissues (HMDB: HMDB0010001)

Tissue

All Tissues (HMDB: HMDB0010001)

Organ

Brain (HMDB: HMDB0010001)

Cellular substructure

Membrane (HMDB: HMDB0010001)
Extracellular (HMDB: HMDB0010001)
Golgi apparatus membrane (PMID: 20519312)
Cell membrane (PMID: 20519312)

Organelle

Endoplasmic reticulum (PMID: 20519312)

Source

Exogenous

Exogenous (HMDB: HMDB0010001)

Food

Animal origin

Poultry

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Endogenous

Endogenous (HMDB: HMDB0010001)

Process

Naturally occurring process

Biological process

Cellular process

Role

Not Available

Physical Properties

Predicted Properties

Property	Value	Source
Water Solubility	0.0044 g/L	ALOGPS
logP	6.89	ALOGPS
logP	10.45	ChemAxon
logS	-5.3	ALOGPS
pKa (Strongest Acidic)	1.08	ChemAxon
pKa (Strongest Basic)	-3.6	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	256.04 Å²	ChemAxon
Rotatable Bond Count	43	ChemAxon
Refractivity	252.4 m³·mol⁻¹	ChemAxon
Polarizability	109.91 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB027187

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

Showing chemical card for PIP(20:1(11Z)/18:2(9Z,12Z)) (CFc000006043)

MOL for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

3D MOL for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

3D SDF for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

3D-SDF for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

PDB for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

3D PDB for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

SMILES for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

INCHI for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

Structure for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))

3D Structure for CFc000006043 (PIP(20:1(11Z)/18:2(9Z,12Z)))