ChemFOnt: Showing chemical card for Chicoric acid (CFc000001602)

Record Information

Version

1.0

Creation Date

2022-08-28 10:25:12 UTC

Update Date

2022-09-13 18:46:16 UTC

Chemfont ID

CFc000001602

Molecule Identification

Common Name

Chicoric acid

Definition

Chicoric acid (CAS: 6537-80-0) is found in the fresh aerial parts of different chicory varieties: green chicory (c.v. Catalogna), two red chicory varieties (radicchio rosso di Chioggia and radicchio rosso di Treviso), and Witloof or Belgian endive. Cichorium sp. L. is a member of the sunflower family (Asteraceae or Compositae), which also includes globe and Jerusalem artichokes, lettuce, and many ornamental plants. It is indigenous to Europe, western Asia, Egypt, and North America. In popular medicine, Cichorium intybus L. has been used to treat skin disorders, such as gout, because of its antihepatotoxic activity. Animal studies have revealed that preparations from chicory roots can lower serum and liver lipid concentration in rats. Cichorium aqueous extracts from roots and aerial parts have been reported for antibacterial activity. Chicory is used as a vegetable, fresh or cooked, while the ground and roasted roots are widely used for blending with coffee powder (PMID: 16076140 ). Chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro (PMID: 15302207 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
D-Chicate	Generator
D-Chicic acid	Generator

Chemical Formula

C₂₂H₁₈O₁₂

Average Molecular Weight

474.3711

Monoisotopic Molecular Weight

474.07982604

IUPAC Name

2,3-bis({[(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy})butanedioic acid

Traditional Name

2,3-bis({[(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy})butanedioic acid

CAS Registry Number

70831-56-0

SMILES

[H]\C(=C(/[H])C1=CC(O)=C(O)C=C1)C(=O)OC(C(OC(=O)C(\[H])=C(\[H])C1=CC(O)=C(O)C=C1)C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3-,8-4-

InChI Key

YDDGKXBLOXEEMN-VHOZIDCHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tetracarboxylic acids and derivatives. These are carboxylic acids containing exactly four carboxyl groups.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Tetracarboxylic acids and derivatives

Direct Parent

Tetracarboxylic acids and derivatives

Alternative Parents

Substituents

Tetracarboxylic acid or derivatives
Cinnamic acid or derivatives
Coumaric acid or derivatives
Hydroxycinnamic acid or derivatives
Cinnamic acid ester
Catechol
Styrene
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Fatty acid ester
Phenol
Monosaccharide
Monocyclic benzene moiety
Fatty acyl
Benzenoid
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Carboxylic acid ester
Carboxylic acid
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Carbonyl group
Organic oxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Physiological effect

Not Available

Disposition

Biological location

Cellular substructure

Membrane (HMDB: HMDB0002375)

Source

Exogenous

Exogenous (HMDB: HMDB0002375)

Food

Vegetable

Leaf vegetable

Lettuce (FooDB: FOOD00095)

Root vegetable

Chicory (FooDB: FOOD00049)

Process

Not Available

Role

Industrial application

Antiviral agent (HMDB: HMDB0002375)

Manufacturing industry

Material processing agent

Coloring agent

Fluorescent agent

Immunological adjuvant (HMDB: HMDB0002375)

Agriculture

Pesticide (HMDB: HMDB0002375)

AntiHIV-integrase (HMDB: HMDB0002375)
Hyaluronidase inhibitor (HMDB: HMDB0002375)

Physical Properties

Predicted Properties

Property	Value	Source
Water Solubility	0.043 g/L	ALOGPS
logP	3.48	ALOGPS
logP	3.02	ChemAxon
logS	-4	ALOGPS
pKa (Strongest Acidic)	2.72	ChemAxon
pKa (Strongest Basic)	-6.3	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	208.12 Å²	ChemAxon
Rotatable Bond Count	11	ChemAxon
Refractivity	113.27 m³·mol⁻¹	ChemAxon
Polarizability	41.97 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB012145

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Chicoric acid

METLIN ID

Not Available

PubChem Compound

45934467

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Zhao, He; Burke, Terrence R., Jr. Facile syntheses of (2R,3R)-(-)- and (2S,3S)-(+)-chicoric acids. Synthetic Communications (1998), 28(4), 737-740.

Showing chemical card for Chicoric acid (CFc000001602)

MOL for CFc000001602 (Chicoric acid)

3D MOL for CFc000001602 (Chicoric acid)

3D SDF for CFc000001602 (Chicoric acid)

3D-SDF for CFc000001602 (Chicoric acid)

PDB for CFc000001602 (Chicoric acid)

3D PDB for CFc000001602 (Chicoric acid)

SMILES for CFc000001602 (Chicoric acid)

INCHI for CFc000001602 (Chicoric acid)

Structure for CFc000001602 (Chicoric acid)

3D Structure for CFc000001602 (Chicoric acid)