ChemFOnt: Showing chemical card for Erythronic acid (CFc000000476)

Record Information

Version

1.0

Creation Date

2022-08-28 10:25:12 UTC

Update Date

2022-09-13 18:44:52 UTC

Chemfont ID

CFc000000476

Molecule Identification

Common Name

Erythronic acid

Definition

Erythronic acid is a sugar component of aqueous humour (eye). It may be derived from glycated proteins or from degradation of ascorbic acid. Erythronic acid is a normal organic acid present in a healthy adult and pediatric population. It has been found in urine, plasma, CSF, and synovial fluid (PMID: 14708889 , 8087979 , 8376520 , 10420182 ). Erythronic acid is formed when N-acetyl-D-glucosamine (GlcNAc) is oxidized. GlcNAc is a constituent of hyaluronic acid (HA), a polysaccharide consisting of alternating units of glucuronic acid and GlcNAc, present as an aqueous solution in synovial fluid. In the synovial fluid of patients suffering from rheumatoid arthritis, HA is thought to be degraded either by radicals generated by Fenton chemistry (Fe2+/H2O2) or by NaOCl generated by myeloperoxidase (PMID: 10614067 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Erythro-2,3,4-trihydroxybutyric acid	ChEBI
Erythro-2,3,4-trihydroxybutyrate	Generator
Erythronate	Generator
(R,r)-2,3,4-trihydroxy-butanoate	HMDB
(R,r)-2,3,4-trihydroxy-butanoic acid	HMDB
2,3,4-Trihydroxybutanoate	HMDB
2,3,4-Trihydroxybutanoic acid	HMDB
D-Erythronate	HMDB
Erythronic acid	ChEBI

Chemical Formula

C₄H₈O₅

Average Molecular Weight

136.1033

Monoisotopic Molecular Weight

136.037173366

IUPAC Name

(2R,3R)-2,3,4-trihydroxybutanoic acid

Traditional Name

erythronic acid

CAS Registry Number

13752-84-6

SMILES

OC[C@@H](O)[C@@H](O)C(O)=O

InChI Identifier

InChI=1S/C4H8O5/c5-1-2(6)3(7)4(8)9/h2-3,5-7H,1H2,(H,8,9)/t2-,3-/m1/s1

InChI Key

JPIJQSOTBSSVTP-PWNYCUMCSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as sugar acids and derivatives. Sugar acids and derivatives are compounds containing a saccharide unit which bears a carboxylic acid group.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Sugar acids and derivatives

Alternative Parents

Substituents

Beta-hydroxy acid
Short-chain hydroxy acid
Sugar acid
Alpha-hydroxy acid
Hydroxy acid
Monosaccharide
Fatty acid
Secondary alcohol
Polyol
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Alcohol
Carbonyl group
Primary alcohol
Hydrocarbon derivative
Organic oxide
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

erythronic acid (CHEBI:37655 )

Functional Ontology

Physiological effect

Not Available

Disposition

Biological location

Non-excretory biofluid

Biofluid or Excreta

Blood (PMID: 8412012)
Cerebrospinal Fluid (CSF) (PMID: 8412012)
Saliva (PMID: 22308371)
Cerebrospinal fluid (HMDB: HMDB0000613)

Organ

Placenta (HMDB: HMDB0000613)

Excreta

Biofluid or Excreta

Urine (PMID: 8087979)
Feces (PMID: 20669995)

Cellular substructure

Cytoplasm (HMDB: HMDB0000613)

Source

Endogenous

Endogenous (HMDB: HMDB0000613)

Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)
Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Bovine

Venison

Deer (FooDB: FOOD00524)
Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)

Caprae

Domestic goat (FooDB: FOOD00529)

Swine

Domestic pig (FooDB: FOOD00536)
Wild boar (FooDB: FOOD00307)

Equine

Horse (FooDB: FOOD00378)

Process

Not Available

Role

Not Available

Physical Properties

Predicted Properties

Property	Value	Source
Water Solubility	488 g/L	ALOGPS
logP	-2.1	ALOGPS
logP	-2.1	ChemAxon
logS	0.55	ALOGPS
pKa (Strongest Acidic)	3.4	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	97.99 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	26.35 m³·mol⁻¹	ChemAxon
Polarizability	11.68 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0000613

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB022143

KNApSAcK ID

C00033834

Chemspider ID

2061231

KEGG Compound ID

Not Available

BioCyc ID

CPD-19877

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

5586

PubChem Compound

2781043

PDB ID

Not Available

ChEBI ID

37655

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Heikkila, Heikki; Alen, Raimo; Kauko, Siru; Lindroos, Mirja; Nurmi, Juha; Sarmala, Paivi; Tylli, Matti. Method for producing xylitol and erythritol from arabinoxylan-containing materials. Eur. Pat. Appl. (2000), 9 pp.

Showing chemical card for Erythronic acid (CFc000000476)

MOL for CFc000000476 (Erythronic acid)

3D MOL for CFc000000476 (Erythronic acid)

3D SDF for CFc000000476 (Erythronic acid)

3D-SDF for CFc000000476 (Erythronic acid)

PDB for CFc000000476 (Erythronic acid)

3D PDB for CFc000000476 (Erythronic acid)

SMILES for CFc000000476 (Erythronic acid)

INCHI for CFc000000476 (Erythronic acid)

Structure for CFc000000476 (Erythronic acid)

3D Structure for CFc000000476 (Erythronic acid)